| Date | Home | Away | Result |
|---|---|---|---|
| 23/09/25 16:00 | Cagliari Calcio | Frosinone Calcio | 4-1 |
| 23/09/25 17:30 | Udinese Calcio | Palermo FC | 2-1 |
| 23/09/25 20:00 | AC Milan | US Lecce | 3-0 |
| 24/09/25 16:00 | Parma Calcio 1913 | Spezia Calcio | 6-5a.PSO |
| 24/09/25 17:30 | Hellas Verona | FC Venice | 4-5a.PSO |
| 24/09/25 20:00 | Como Calcio | Sassuolo Calcio | 3-0 |
| 25/09/25 17:30 | Genua CFC | FC Empoli | 3-1 |
| 25/09/25 20:00 | FC Turin | Pisa Sporting Club | 1-0 |